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Dr. Curatola actually created the first prebiotic toothpaste, called Revitin. "Probiotics  don't work in the mouth because the oral microbiome is very inhospitable for foreign bacteria to set up shop," says Curatola. Prebiotics, on the other hand, can have an  effect on your oral microbiome, and "foster balance, nourish, and support a healthy  balance of oral bacteria.