The Sialo-Microbial-Dental Complex Explained

By Gerry Curatola | Jul 04, 2025

The sialo-microbial-dental complex is a critical piece of your oral health, dental remineralization, and whole body wellness. It refers to the relationship between harmful and beneficial bacteria in your saliva and on your teeth.

This term is used more in holistic dentistry settings, but conventional and mainstream dentists are starting to acknowledge the importance of bacterial balance in your saliva and on your teeth.

Below, we’ll talk about dietary changes and other ways to support your microbial ecosystem and this complex. Keep reading to learn more about how the bacteria in your mouth and on your teeth may not be harmful as long as your sialo-microbial-dental complex is in balance.

What Is the Sialo-Microbial-Dental Complex?

The sialo-microbial-dental complex refers to the multi-directional relationship between your saliva (sialo-), your oral bacteria and biofilms (microbial-), and your teeth (dental). The delicate balance of this complex determines your dental health, oral health, and systemic wellness.

Saliva plays a vital role in this complex. At its ideal pH of 6.5-7.4, saliva can wash away food particles and acids from your teeth while delivering essential minerals and beneficial biofilm to your teeth.

What’s a biofilm? A biofilm is a matrix of microorganisms, including commensal bacteria, with strong adhesion to your teeth that could be helpful or harmful depending on the balance or dysbiosis of your oral microbiome.

When your microbiome is balanced, biofilms can be protective. Harmful Streptococci bacteria and other aciduric strains are reduced, risk factors for oral disease are lowered, and tooth decay may be reversed.

When your microbiome is in dysbiosis, biofilm proliferation can be harmful. The most cariogenic and acidogenic bacteria, like Streptococcus mutans, dominate biofilm composition. These bacteria consume carbohydrates and excrete acids that lead to enamel erosion.

Harmful biofilms are becoming more and more resistant to antibacterial medication, so it’s more important than ever to naturally balance your oral microbiome to decrease harmful biofilms and increase beneficial biofilms.

The sialo-microbial-dental is a way for cutting-edge dentists and researchers to discuss how dental biofilm can actually help fight dental caries lesions in a diverse, balanced oral microbiome, redefining the etiology of adult-onset and early childhood caries.

The relationship between oral microbes and dental health can be symbiotic, not just pathogenic. It all depends on taking care of your oral microflora, though, so that the sialo-microbial-dental complex supports a balanced remineralization-demineralization cycle.

The Natural Cycle of Remineralization

Remineralization is the natural process of a healthy oral microbiome. It restores important minerals like calcium and phosphate to teeth, strengthening them and fighting tooth decay.

Demineralization refers to the process of vital minerals like calcium and phosphate being removed from your teeth, weakening your dental structure and contributing to cavities.

Demineralization isn’t that bad when it’s part of the natural demineralize-remineralize cycle your microbiome goes through. Modern diets, bad oral hygiene, and poor lifestyle choices can lead to a dysbiotic sialo-microbial-dental complex and more demineralization than remineralization.

You can support your sialo-microbial-dental complex’s natural remineralization of teeth with a healthy diet, a consistent oral hygiene routine, targeted lifestyle changes, and high-quality supplements.

The Modern Diet and Biofilm Imbalance 

For thousands of years, our ancestors had acidic diets and no oral hygiene routine, yet tooth decay was not as prevalent as it is today. Modern experts argue that the rise of processed foods, refined sugars, and ubiquitous acidic drinks has increased the prevalence of tooth decay.

Processed foods, sugars, and acidic drinks are generally harmful to our oral health. These major components of our modern diet disrupt biofilm diversity and function.

A biofilm is a matrix of bacteria and microorganisms, a lattice of microbes found on your tooth surface. Your diet and oral hygiene routine influence whether this biofilm helps or hurts your teeth and gums.

When your oral microbiome is out of balance and more acidic, dental biofilm releases acid and contributes to dental erosion and cavities. However, when your microbiome is healthy, biofilm may also contribute to remineralization of teeth — the opposite of tooth decay.

Biofilm doesn’t have to be a negative; it all depends on the homeostasis of your oral microbiome.

Foods to Avoid

You should avoid the following foods, which disrupt your microbiome and sialo-microbial-dental complex, leading to demineralization and periodontal disease:

  • Refined carbohydrates (particularly sugars and starches)

  • Processed foods

  • White wheat flour

  • Sugar-sweetened beverages

  • Highly acidic food and drink

Foods to Eat

The following foods may support your sialo-microbial-dental complex and promote balanced biofilm that remineralizes teeth and doesn’t erode your enamel:

  • Fruits

  • Vegetables

  • Legumes

  • Fiber

  • Vitamins C and D

  • Omega-3 fatty acids

  • Prebiotic and probiotic foods

  • Anti-inflammatory foods

Supporting the Microbiome Holistically 

You need to support a balanced oral microbiome through biologic practices and natural treatments, in order to promote the sialo-microbial-dental complex and natural teeth remineralization.

Below are the oral hygiene products you should avoid and those you should consider using to support your salivary content, dental strength, and microbial diversity.

Ditch the Harmful Products

Oral hygiene products may actually harm your oral health. For many years, the focus has been on antimicrobial interventions. However, any dentist worth their salt should now know that killing bad bacteria often means killing good bacteria, too, which is a net negative for the patient.

Avoid antibacterial oral hygiene products, like most mouthwashes, that also dry out your mouth. Don’t use antibacterial toothpaste, including “natural” toothpastes that are designed to “control” microbe levels. Antibacterial products are a net negative on salivary bacteria and dental biofilms.

Until further studies absolve them, I would avoid any product that contains xylitol or erythritol as a “natural sweetener.” They may help the microbiome locally, but hurt the cardiovascular system.

Only use soft-bristled toothbrushes. Hard bristles can damage the dental enamel (the “dental” part of the sialo-microbial-dental complex).

Learn More: Is Xylitol Actually Good for Teeth?

A lot of common toothpaste ingredients were designed before we understood the importance of the sialo-microbial-dental complex and have not been reformulated in light of the past decade of convincing evidence. Avoid these common toothpaste ingredients that harm your microbiome:

  • Alcohols

  • Chlorhexidine

  • Sodium lauryl sulfate (SLS)

  • Triclosan

  • Peroxides

  • Artificial flavoring or artificial coloring

  • Artificial sweeteners

Fluoride and hydroxyapatite toothpastes may not negatively impact your sialo-microbial-dental complex. Still, they are likely to lead to other whole-body health issues, so I can’t recommend them either.

Beware, even all-natural toothpastes may proudly and misguidedly use antibacterial ingredients. “Natural” is better than chemical, but “natural” isn’t necessarily good for your oral microflora.

Try These Microbiome-Supporting Products

Some oral hygiene products actually support your oral microbiota and the sialo-microbial-dental complex, instead of killing good bacteria, drying out the mouth, and causing systemic health issues.

First and foremost, feed your oral microbiome with prebiotics and probiotics. Dental or oral probiotics are good supplements to add to your oral hygiene routine, but more evidence is needed to know exactly which strains of beneficial bacteria are most healthful.

A prebiotic toothpaste like Revitin supports your microbiome and sialo-microbial-dental complex more than any other toothpaste.

Oil pulling with coconut oil is an excellent alternative to mouthwash. It raises the pH in your mouth, making it a less acidic environment, while washing away food particles and interdental plaque. It can stimulate saliva production, supporting the sialo-microbial-dental complex.

Rinsing your mouth out with water is better than conventional mouthwash, as well as not rinsing your mouth at all. It hydrates your oral cavity, washes away food debris, and raises the pH in your mouth, making it less acidic.

FAQs

Can chemical mouthwash agents control plaque and gingivitis?

Chemical mouthwash kills bacteria. For decades, that has been seen as a benefit to plaque and gingivitis. Now, experts understand that the common chlorhexidine mouthwash kills both good and bad bacteria and also dries out the mouth.

Both of these side effects mean that chemical mouthwash throws the oral microbiome into dysbiosis, increasing harmful plaque and gingivitis pathogenesis risk, and destroying the sialo-microbial-dental complex’s ability to remineralize teeth.

How do bacterial pathogens apply to the sialo-microbial-dental complex?

The concept of the sialo-microbial-dental complex reveals that the biofilm on your teeth may contain bacterial pathogens (harmful) when in dysbiosis, but dental biofilm may contain beneficial bacteria when your microbiome is balanced.

Bacteria can be beneficial if the rest of your mouth is healthy. More awareness of bacterial pathogens and beneficial oral bacteria would improve public health outcomes.

A Cleaner, Healthier Smile Starts Here

To maintain a healthy sialo-microbial-dental complex and reduce your risk of tooth decay and other oral health issues, you need to make targeted dietary changes, ensure regular hydration, and boost your oral hygiene routine with probiotics and prebiotics.

Try Revitin, the world’s first prebiotic toothpaste. Developed by the nation’s leading biologic dentist, Revitin was made to support your oral microbiome, your sialo-microbial-dental complex, and your mouth’s natural ability to heal itself.

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