CoQ10 In Toothpaste: What It Does and Why It Matters

Most people think of oral care as brushing, flossing, mouthwash, and regular dental checkups. But did you know the ingredients in your toothpaste can have a huge impact on your dental health (and, by extension, your whole-body health)?

Coenzyme Q10 (CoQ10 for short) is a popular toothpaste ingredient with powerful antioxidant properties to support better gum health and a balanced oral microbiome.

Let’s discuss CoQ10, how it supports oral health, and whether you should look for it in your next tube of toothpaste.

What Is CoQ10?

CoQ10 (Coenzyme Q10 or ubiquinone) is a naturally occurring fat-soluble coenzyme found in every cell on the planet. It plays a vital role in cellular energy production, particularly within the mitochondria. Found in high concentrations in the heart, liver, and gums, CoQ10 acts as a powerful antioxidant and an essential factor in cellular regeneration. 

CoQ10 helps enzymes carry out functions critical to cellular energy production and antioxidant defense. It also contributes to healthy oral tissues by combating oxidative stress, supporting tissue regeneration, and aiding in energy production at the cellular level. [1]

Increasing the CoQ10 levels in your gum tissue can promote healthy cell function, reduce inflammation, and protect tissues from oxidative damage caused by free radicals. 

As you age, your natural CoQ10 levels decline. This is one reason — though certainly not the only reason — that gum disease is so common for adults over 45.

Why It Belongs in Your Oral Care Routine

As a biologic dentist who has seen countless patients struggling with periodontitis, I’m a big believer that CoQ10 can play an important part in your daily oral care. It’s one ingredient proven to improve oral health by keeping inflammation in the gums at bay and supporting a healthy, balanced oral microbiome.

1. Healthier Gums, Naturally

When applied topically, CoQ10 supports healthier gums with less inflammation and irritation after scaling and root planing (SRP) procedures on patients with periodontal disease. [2]

Studies have shown that individuals with gum disease often have lower CoQ10 levels in their oral tissue. Supplementing CoQ10, both orally and topically, may help manage and improve symptoms of gingivitis and periodontitis. [3]

By improving mitochondrial function in gum tissues, CoQ10 promotes tissue repair and reduces gum bleeding and swelling. Its natural antioxidant properties neutralize harmful free radicals, allowing your gums to heal and stay strong. 

2. A Balanced Oral Microbiome

A balanced oral microbiome is essential to prevent cavities, gum disease, and bad breath. CoQ10 toothpaste supports the natural balance of good bacteria in the mouth while helping to reduce the presence of harmful bacteria. (For the science lovers among us, this relationship between the oral microbiome and overall dental/oral health is called the sialo-microbial-dental complex.)

Most of the research here focuses on how CoQ10 balances the oral microbiome and prevents some pathogenic bacteria from causing damage to gum tissue. However, its impact on the S. mutans bacteria and effects combined with SRP also improve the overall condition of the oral microbiome. [4]

What does this mean for CoQ10 toothpaste? In short, it can serve as a great benefit to your oral care routine! It may serve to not only keep your gums healthy, but also support remineralization of your enamel and fresh breath. (Plus, many toothpastes that contain CoQ10 also don’t use the harsh chemicals and preservatives you might find in commercial toothpaste.)

Revitin uses CoQ10, along with many other natural ingredients, to offer you a toothpaste built for a better oral microbiome.

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Why Revitin Includes CoQ10 in Its Formula

When developing Revitin’s formula, I insisted we include CoQ10 for its clinically-backed benefits. CoQ10 in toothpaste works synergistically with vitamin C, enzymes, and essential oils to:

• Reduce gum inflammation

• Support healthy bacterial balance

• Strengthen tooth enamel naturally

Unlike traditional toothpaste that may contain sulfates and artificial additives, Revitin offers a safe, natural alternative using ingredients like:

• CoQ10 (Ubiquinone): A key factor in cellular health that promotes gum regeneration.

• MSM (methylsulfonylmethane): Supports connective tissue and stimulates stem cells in the periodontal ligaments.

• Sea Buckthorn: Superfood rich in vitamin C, vitamin E, and omega fatty acids that help reduce inflammation and support cellular repair.

• Calcium Carbonate & Silica: Gently whiten teeth while helping remineralize enamel.

• Vitamins D3 & K2: Strengthen enamel, support bone metabolism, and reduce inflammation.

• Vitamin C & Folic Acid: Boost gum health and cellular function.

• Non-GMO Vegetable Glycerin: Maintains moisture and smooth texture, aiding gentle application without disrupting the oral microbiome.

• Natural Flavors like Spearmint, Citrus, and Piperita: Deliver fresh breath without artificial additives.

This natural toothpaste excludes harmful ingredients such as sodium lauryl sulfate (SLS), parabens, artificial sweeteners, and fluoride. It’s also GMO-free, gluten-free, and safe for adults and children.

Read Next: Oral Prebiotics: What They Are and Why You Need Them

Safety Considerations

CoQ10 is considered safe for both oral and topical use for people of all ages. According to the NIH, most people tolerate it well, even in high doses [5]. Revitin uses CoQ10 within safe topical concentrations, making it suitable for daily use in both children and adults.

In rare cases, some people react poorly to CoQ10. Side effects may include:

• Loss of appetite

• Fatigue

• Headaches

• Skin rash or itching

• Nausea

• Heartburn

• Trouble sleeping

• Irritability

If you notice any of these symptoms after switching to a CoQ10 toothpaste (or supplementing with CoQ10 orally), stop using the product immediately and talk to your doctor about your symptoms.

Read Next: Is Stevia Bad for Your Teeth?

FAQs

What ingredients should be avoided in toothpaste?

Avoid these harmful ingredients in your toothpaste:

• Sodium lauryl sulfate (SLS): Can cause mouth irritation.

• Triclosan: May disrupt hormones.

• Artificial sweeteners & dyes: Linked to allergic reactions.

• Xylitol: May disrupt the oral and gut microbiome.

• Propylene glycol: Industrial chemical with questionable safety.

• Fluoride: Linked to dental fluorosis and toxicity concerns.

• Nano-hydroxyapatite: Very tiny particles may be absorbed into undesirable areas of the body.

Is Revitin fluoride-free?

Yes. Revitin is 100% fluoride-free. Instead, it uses natural ingredients such as CoQ10, calcium carbonate, and essential oils to maintain strong enamel and gum health without the risks linked to fluoride overexposure.

What’s the best toothpaste for oral health?

The best toothpaste for oral health should be:

• Oral microbiome-friendly

• Fluoride-free

• Rich in antioxidants like CoQ10

• Remineralizing (using calcium carbonate and hydroxyapatite)

• Free from SLS, parabens, and artificial sweeteners

Revitin checks all these boxes, making it one of the best toothpaste options if you’re seeking a natural but effective oral health solution.

Read Next: Benefits of Cranberry Seed Oil in Toothpaste

A Healthier Smile Starts at the Cellular Level

The benefits of CoQ10 in natural toothpaste extend far beyond just cleaning teeth. CoQ10 toothpaste offers antioxidant support, protects and heals gum tissue, and promotes a balanced oral microbiome.

Revitin is a CoQ10-infused toothpaste that supports oral health — free from fluoride, GMOs, SLS, parabens, and artificial sweeteners. This microbiome-friendly, natural alternative helps prevent gum disease, reduces inflammation, whitens teeth, and promotes remineralization.

Make the switch to a natural toothpaste with CoQ10 today to experience oral care that supports your body at the cellular level.

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Sources

1. Sood, B., Patel, P., & Keenaghan, M. (2024). Coenzyme Q10. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK531491/ 

2. Manthena, S., Rao, M. V., Penubolu, L. P., Putcha, M., & Harsha, A. V. (2015). Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health. Journal of clinical and diagnostic research: JCDR, 9(8), ZC26–ZC28. https://doi.org/10.7860/JCDR/2015/13486.6291

3. Prakash, S., Sunitha, J., & Hans, M. (2010). Role of coenzyme Q(10) as an antioxidant and bioenergizer in periodontal diseases. Indian journal of pharmacology, 42(6), 334–337. https://doi.org/10.4103/0253-7613.71884 

4. Khodaii, Z., Mardi, S., Mardi, P., & Natanzi, M. M. (2023). Adjunctive role of Q10 with Ligilactobacillus salivarius, and Lactiplantibacillus plantarum probiotic Bacteria on the HEp-2 cells viability and adhesion of Streptococcus mutans. Frontiers in Cellular and Infection Microbiology, 13, 1053230. https://pmc.ncbi.nlm.nih.gov/articles/PMC10175631/

5. Ghasemi, S., Torab, Z., Shirmohammadi, A., Babaloo, A., Johari, R., Farhadi, F., Mobasseri, M., & Mohammadi, H. (2022). Evaluation of the effect of coenzyme Q10 supplementation along with scaling and root planing (SRP) on periodontal and gingival indices in controlled diabetic patients. Journal of advanced periodontology & implant dentistry, 14(1), 32–37. https://doi.org/10.34172/japid.2022.003